Chronic Inflammatory Demyelinating Polyradiculoneuropathy, in an 8-Year-Old Girl, Complicated by Deafness and Kidney Fibrosis

• Published in: Journal of child neurology Vol. 24; no. 8; pp. 997 - 1000
• Main Authors: Stojanovic, Vesna D., Doronjski, Aleksandra R., Spasojevic, Slobodan D., Pavlovic, Vesna S., Nikolic, Marko M., Kovacevic, Branka B.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01-08-2009
• Subjects: Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Child; Deafness - complications; Deafness - drug therapy; Female; Fibrosis - complications; Fibrosis - drug therapy; Humans; Immunoglobulins, Intravenous - therapeutic use; Immunologic Factors - therapeutic use; Kidney Diseases - complications; Kidney Diseases - drug therapy; Methylprednisolone - therapeutic use; Mycophenolic Acid - analogs & derivatives; Mycophenolic Acid - therapeutic use; Neural Conduction; Neuroprotective Agents - therapeutic use; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - complications; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - drug therapy; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - physiopathology; Treatment Outcome; chronic inflammatory demyelinating polyradiculoneuropathy; deafness; kidney fibrosis
• ISSN: 0883-0738; 1708-8283
• DOI: 10.1177/0883073808331353

Based on case history and clinical and electrophysiological examinations, the authors report on a case of an 8-year-old girl who was diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy. The disease was complicated by deafness and kidney fibrosis. During treatment with methylprednisolone and intravenous immunoglobulin, followed by mycophenolate mofetil, prompt improvement of neurological findings occurred. The improvement of hearing was poor. Because the pathogenesis of chronic inflammatory demyelinating polyradiculoneuropathy has still not been clear, and on the grounds of several cases of chronic inflammatory demyelinating polyradiculoneuropathy conjoined with the kidney disease described in literature (glomerulopathy, interstitial nephritis), every patient with chronic inflammatory demyelinating polyradiculoneuropathy needs to undergo the urinalyses.