Neuronal tuning and population representations of shape and category in human visual cortex

• Published in: Nature communications Vol. 15; no. 1; pp. 4608 - 15
• Main Authors: Bougou, Vasiliki, Vanhoyland, Michaël, Bertrand, Alexander, Van Paesschen, Wim, Op De Beeck, Hans, Janssen, Peter, Theys, Tom
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30-05-2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/2613/2614; 631/378/2613/2616; 9/30; 9/97; Adult; Animals; Arrays; Brain research; Cognition & reasoning; Decoders; Epilepsy; Female; Firing pattern; Humanities and Social Sciences; Humans; Information processing; Male; multidisciplinary; Neural coding; Neuroimaging; Neurons; Neurons - physiology; Neurosciences; Neurosurgery; Object recognition; Patients; Pattern recognition; Pattern Recognition, Visual - physiology; Photic Stimulation; Representations; Science; Science (multidisciplinary); Tuning; Visual cortex; Visual Cortex - physiology; Visual Pathways - physiology; Young Adult
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-024-49078-3

Object recognition and categorization are essential cognitive processes which engage considerable neural resources in the human ventral visual stream. However, the tuning properties of human ventral stream neurons for object shape and category are virtually unknown. We performed large-scale recordings of spiking activity in human Lateral Occipital Complex in response to stimuli in which the shape dimension was dissociated from the category dimension. Consistent with studies in nonhuman primates, the neuronal representations were primarily shape-based, although we also observed category-like encoding for images of animals. Surprisingly, linear decoders could reliably classify stimulus category even in data sets that were entirely shape-based. In addition, many recording sites showed an interaction between shape and category tuning. These results represent a detailed study on shape and category coding at the neuronal level in the human ventral visual stream, furnishing essential evidence that reconciles human imaging and macaque single-cell studies.
The tuning properties of ventral stream neurons for object shape and category are not fully understood. Here the authors carry out multi-electrode array recordings in lateral occcipital complex and find that object properties are largely shape-based.