A simple method to study cellular migration

We describe here a simple and fast method for the characterisation of cell motion. By projecting on a single plane different positions of the cell a ribbon is generated, whose characteristics can be related to the type of motion. The proposed method allows both to determine, very quickly, the motili...

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Bibliographic Details
Published in:	Journal of neuroscience methods Vol. 141; no. 2; pp. 271 - 276
Main Authors:	Ariano, P., Distasi, C., Gilardino, A., Zamburlin, P., Ferraro, M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15-02-2005
Subjects:	Animals bFGF Cell Movement - drug effects Cell Movement - physiology Cells, Cultured Chick Embryo Computational methods Computer Graphics Computer Simulation Dose-Response Relationship, Drug Embryonic ciliary ganglion neurons Fibroblast Growth Factors - pharmacology GDNF Glial Cell Line-Derived Neurotrophic Factor Image Processing, Computer-Assisted - methods Migration Models, Biological Nerve Growth Factors - pharmacology Computational methods GDNF Migration bFGF Embryonic ciliary ganglion neurons
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Summary:	We describe here a simple and fast method for the characterisation of cell motion. By projecting on a single plane different positions of the cell a ribbon is generated, whose characteristics can be related to the type of motion. The proposed method allows both to determine, very quickly, the motility of a population of cells and to investigate and characterise properties of a single cell’s motion. The methodology presented here can be applied to a large range of cell movement and also adapted and extended to other problems involving biological motion.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0165-0270 1872-678X
DOI:	10.1016/j.jneumeth.2004.07.001