Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases

• Published in: Drug metabolism reviews Vol. 53; no. 1; pp. 100 - 121
• Main Authors: Upadhyay, Arun, Amanullah, Ayeman, Joshi, Vibhuti, Dhiman, Rohan, Prajapati, Vijay Kumar, Poluri, Krishna Mohan, Mishra, Amit
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02-01-2021
• Subjects: COX; ibuprofen; neurodegeneration; neuroprotection; NSAIDs; neurodegeneration; ibuprofen; COX; NSAIDs; neuroprotection
• ISSN: 0360-2532; 1097-9883
• DOI: 10.1080/03602532.2021.1903488

Ibuprofen is a classical nonsteroidal anti-inflammatory drug (NSAID) highly prescribed to reduce acute pain and inflammation under an array of conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhea, and gout. Ibuprofen acts as a potential inhibitor for cyclooxygenase enzymes (COX-1 and COX-2). In the past few decades, research on this small molecule has led to identifying other possible therapeutic benefits. Anti-tumorigenic and neuroprotective functions of Ibuprofen are majorly recognized in recent literature and need further consideration. Additionally, several other roles of this anti-inflammatory molecule have been discovered and subjected to experimental assessment in various diseases. However, the major challenge faced by Ibuprofen and other drugs of similar classes is their side effects, and tendency to cause gastrointestinal injury, generate cardiovascular risks, modulate hepatic and acute kidney diseases. Future research should also be conducted to deduce new methods and approaches of suppressing the unwanted toxic changes mediated by these drugs and develop new therapeutic avenues so that these small molecules continue to serve the purposes. This article primarily aims to develop a comprehensive and better understanding of Ibuprofen, its pharmacological features, therapeutic benefits, and possible but less understood medicinal properties apart from major challenges in its future application.
KEY POINTS
Ibuprofen, an NSAID, is a classical anti-inflammatory therapeutic agent.
Pro-apoptotic roles of NSAIDs have been explored in detail in the past, holding the key in anti-cancer therapies.
Excessive and continuous use of NSAIDs may have several side effects and multiple organ damage.
Hyperactivated Inflammation initiates multifold detrimental changes in multiple pathological conditions.
Targeting inflammatory pathways hold the key to several therapeutic strategies against many diseases, including cancer, microbial infections, multiple sclerosis, and many other brain diseases.