Clinical improvement, toxicity and future prospects of β-sitosterol: a review

• Published in: CYTA: journal of food Vol. 22; no. 1
• Main Authors: Durrani, Azka Khan, Khalid, Momina, Raza, Awais, Faiz ul Rasool, Izza, Khalid, Waseem, Akhtar, Muhammad Nadeem, Ahmad Khan, Ammar, Abdullah, Zunair, Khadijah, Babirye
• Format: Journal Article
• Language: English
• Published: Taylor & Francis Group 31-12-2024
• Subjects: coronary artery disease; deoxyxylulose and mevalonate pathway; low density lipoprotein (LDL); Phytosterols; stanol esters
• ISSN: 1947-6337; 1947-6345
• DOI: 10.1080/19476337.2024.2337886

ABSTRACTβ-sitosterol is waxy substance, white in color distributed in a variety of natural plant sources cereals, pulses, legumes, vegetables, fruits, and herbs. Several clinical and preclinical investigations indicate that β-sitosterol has a wide range of important health advantages. It prevents many types of malignancies, lowers levels of low density lipoprotein (LDL), lowers the risk of coronary artery disease, heart attacks, and atherosclerosis, and supports the body’s natural healing process. It is found to have cancer-protective properties and has the potency to be beneficial against breast, prostate, colon, lung, stomach, and leukemia. The present review provides a complete analysis and examines the literature on β-sitosterol from different dietary sources, with a focus on its toxicological characteristics and nutraceutical qualities. It lays down the theoretical basis and justification for directing the future planning and execution of clinical studies intended to confirm the importance and possible toxicity of β-sitosterol.