Multicomponent synthesis via acceptorless alcohol dehydrogenation: an easy access to tri-substituted pyridines

Multicomponent synthesis via acceptorless alcohol dehydrogenation: an easy access to tri-substituted pyridines

Herein, we report palladium supported on a hydroxyapatite catalyst for synthesizing tri-substituted pyridines using ammonium acetate as the nitrogen source acceptorless alcohol dehydrogenation strategy. The strategy offers a broad substrate scope using inexpensive and readily available alcohols as t...

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Bibliographic Details
Published in:RSC advances Vol. 14; no. 15; pp. 10761 - 10767
Main Authors: P, Hima, M, Vageesh, Dey, Raju
Format: Journal Article
Language:English
Published: England Royal Society of Chemistry 26-03-2024
The Royal Society of Chemistry
Subjects:
Alcohols
Ammonium acetate
Catalysts
Chemical synthesis
Chemistry
Dehydrogenation
Hydroxyapatite
Infrared spectroscopy
Oxidation
Palladium
Pyridines
Substitutes
Substrates
Valence
X ray photoelectron spectroscopy
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Summary:Herein, we report palladium supported on a hydroxyapatite catalyst for synthesizing tri-substituted pyridines using ammonium acetate as the nitrogen source acceptorless alcohol dehydrogenation strategy. The strategy offers a broad substrate scope using inexpensive and readily available alcohols as the starting material. The catalyst was prepared using a simple method and analyzed by several techniques, including FE-SEM, EDS, HR-TEM, BET, XRD, FT-IR, UV-visible spectroscopy, and XPS, demonstrating the anchoring of Pd nanoparticles on hydroxyapatite in the zero oxidation state. Moreover, several controlled experiments were carried out to understand the reaction pathway and a suitable mechanism has been proposed.
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ISSN:2046-2069
2046-2069
DOI:10.1039/d4ra00439f