Economic burden following allogeneic hematopoietic stem cell transplant in patients with diffuse large B-cell lymphoma

• Published in: Leukemia & lymphoma Vol. 59; no. 5; pp. 1133 - 1142
• Main Authors: Maziarz, Richard T., Hao, Yanni, Guerin, Annie, Gauthier, Genevieve, Gauthier-Loiselle, Marjolaine, Thomas, Simu K., Eldjerou, Lamis
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 04-05-2018
• Subjects: Adolescent; Adult; Aged; allogeneic hematopoietic stem cell transplant; Cross-Sectional Studies; Diffuse large B-cell lymphoma; economic burden; Female; Follow-Up Studies; Health Care Costs; healthcare costs; healthcare resource utilization; Hematopoietic Stem Cell Transplantation - economics; Hematopoietic Stem Cell Transplantation - methods; Humans; Lymphoma, Large B-Cell, Diffuse - economics; Lymphoma, Large B-Cell, Diffuse - pathology; Lymphoma, Large B-Cell, Diffuse - therapy; Male; Middle Aged; Prognosis; Retrospective Studies; Survival Rate; Transplantation, Homologous; Young Adult; allogeneic hematopoietic stem cell transplant; economic burden; healthcare costs; healthcare resource utilization; Diffuse large B-cell lymphoma
• ISSN: 1042-8194; 1029-2403
• DOI: 10.1080/10428194.2017.1375100

This study describes short-term and long-term healthcare resource utilization (HRU) and costs following an allogeneic hematopoietic stem cell transplant (HSCT) in adult patients with diffuse large B-cell lymphoma (DLBCL) in a real-world setting. Among 101 patients with DLBCL receiving an allogeneic HSCT, HRU and direct healthcare costs for up to three years after the allogeneic HSCT are described. HRU and costs were substantial, with the most intensive HRU and highest healthcare costs observed during the first year after HSCT (38 inpatient days; 68 days with office visits and average healthcare costs of $455,741). Although HRU and costs decreased over time, they remained high even in the third year after HSCT (four inpatient days; 27 days with office visits and average healthcare costs of $72,957). Overall, this study showed that the economic burden following an allogeneic HSCT in DLBCL patients is significant.