Patient Outcomes of Henoch-Schönlein Purpura Nephritis According to the New Semiquantitative Classification

• Published in: Fetal and pediatric pathology Vol. 39; no. 5; pp. 381 - 389
• Main Authors: Yel, Sibel, Dursun, Ismail, Pinarbaşi, Ayşe Seda, Günay, Neslihan, Özdemir, Sümeyra, Şahin, Nihal, Akgün, Hülya, Ipekten, Funda, Poyrazoğlu, Hakan, Düşünsel, Ruhan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02-09-2020
• Subjects: Biopsy; Child; children; glomerulonephritis; histology; Humans; Nephritis; Purpura, Schoenlein-Henoch; renal biopsy; semiquantitative; Vasculitis; semiquantitative; histology; glomerulonephritis; children; vasculitis; renal biopsy
• ISSN: 1551-3815; 1551-3823
• DOI: 10.1080/15513815.2019.1658245

Background: A new semiquantitative classification (SQC) for pediatric Henoch-Schönlein nephritis (HSN) was defined recently. The outcomes of pediatric HSN patients are reevaluated according to the new classification. Methods: Primary kidney biopsies from 80 HSN patients were scored using the new SQC. The International Study of Kidney Disease in Children (ISKDC) and SQC classifications were compared in terms of the patient outcomes. Outcomes were defined as: Outcome A (n = 44) patients with no sign of renal disease, Outcome B (n = 32) patients with minor urinary abnormalities, and Outcome C (n = 4) patients with active renal disease. Results: The patients with outcome C had significantly higher biopsy scores and chronicity indices than patients in group A. There was no significant difference in areas under the curve between total biopsy SQC scores and ISKDC findings. Conclusions: Our results suggest that the modified SQC is not more sensitive than ISKDC classification for predicting the outcome in HSN cases.