Cyclodextrin-based dextromethorphan potentiometric sensors

• Published in: Journal of electroanalytical chemistry (Lausanne, Switzerland) Vol. 661; no. 1; pp. 239 - 244
• Main Authors: Khaled, Elmorsy, Kamel, Manal S., Hassan, Hassan N.A., Aboul-Enein, Hassan Y.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01-10-2011; Elsevier
• Subjects: Analysis; automation; Biological and medical sciences; Chemistry; Coated wire electrodes; compliance; Cyclodextrins; detection limit; Dextromethorphan; drug formulations; Electrochemistry; electrodes; Electrodes: preparations and properties; Exact sciences and technology; Flow injection analysis; General and physical chemistry; General pharmacology; graphene; ionophores; Medical sciences; Other electrodes; Pharmaceutical formulations; Pharmacology. Drug treatments; plasticizers; Potentiometric sensors; shelf life; sodium; Coated wire electrodes; Cyclodextrins; Dextromethorphan; Potentiometric sensors; Flow injection analysis; Pharmaceutical formulations; Morphinan derivatives; Chemical analysis; Opiates; Alkaloid; Tablet; Polyvinyl chloride; Flow injection; Modified material; Membrane electrode; Oral form; Transition metal; Antitussive agent; Potentiometry; Electrochemical detector; Wire electrode; Drop; Silver; Cyclodextrin; Preparation; Graphite; Dosage form; Inclusion compound
• ISSN: 1572-6657; 1873-2569
• DOI: 10.1016/j.jelechem.2011.08.008

The construction and performance characteristics of different dextromethorphan (DXM) – PVC, silver coated wire (CWE) and coated graphite (CGE), potentiometric sensors are described. Sensors incorporated with 2,3,6-tri-o-methyl-β-CD as sensing ionophore, sodium tetrakis (4-fluorophenyl) borate (NaTFPB) as anionic site and o-nitrophenyloctylether (o-NPOE) as membrane plasticizer showed the best electroanalytical performances. CWEs work satisfactorily in the concentration range from 10−7 to 10−2molL−1 (detection limit 7.0×10−8molL−1) with fast response time of about 4s and operational lifetime 4weeks. The developed electrodes have been successfully applied for the potentiometric determination of DXM in pharmaceutical formulation under batch and flow injection analysis (FIA) conditions. [Display omitted]
► The construction and performance characteristics of different dextromethorphan (DXM) potentiometric sensors are described. ► The cited electrodes are based on β-cyclodextrin as sensing ionophore. ► The detection limit was improved by almost two orders of magnitude. ► The developed sensors were applied for the potentiometric determination of DXM in pharmaceutical formulations.
The construction and performance characteristics of different dextromethorphan (DXM) potentiometric sensors are described. Three types of electrodes are demonstrated, namely silver coated wire electrode (CWE), coated graphite electrode (CGE) and the conventional PVC membrane electrodes (CE). The cited electrodes are based on cyclodextrins (CDs) ionophores and show a considerable selectivity towards DXM with Nernstian slopes depending on the type of the electrode and the ionophore used. Matrix compositions of each electrode are optimized on the basis of effects of type and concentration of the ionophore as well as influence of the selected plasticizers. CWE incorporated with heptakis (2,3,6-tri-o-methyl)-β-CD and sodium tetrakis (4-fluorophenyl) borate (NaTFPB) with o-nitrophenyloctylether (o-NPOE) as membrane plasticizer, showed the best electroanalytical performances. CWEs work satisfactorily in the concentration range from 10−7 to 10−2molL−1 with Nernstian compliance 59.0±0.22mVdecade−1 and detection limit 7.0×10−8molL−1. Fast response time of about 4s and adequate shelf-life (4weeks) was achieved. The developed electrodes have been successfully applied for the potentiometric determination of DXM in pharmaceutical formulation under batch and flow injection analysis (FIA) conditions. FIA allows the analysis of 90samplesh−1 and offer the advantage of simplicity, accuracy and automation feasibility. Comparison of the obtained results with those provided by reference method revealed adequate accuracy for control assay.