Heteropolyacid-clay nano-composite as a novel heterogeneous catalyst for the synthesis of 2,3-dihydroquinazolinones

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 19; no. 2; pp. 407 - 412
• Main Authors: Dar, Bashir A., Sahu, Akshya K., Patidar, Praveen, Sharma, Parduman R., Mupparapu, Nagaraju, Vyas, Dushyant, Maity, Sudip, Sharma, Meena, Singh, Baldev
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25-03-2013; 한국공업화학회
• Subjects: Bonding; Catalysis; Catalysts; Condensation; Cyclization. Heterogeneous catalysis; Nano-composite; Nanocomposites; Nanomaterials; Nanostructure; Purification; Recycled; Synthesis; 화학공학; Cyclization. Heterogeneous catalysis; Catalysis; Condensation; Nano-composite
• ISSN: 1226-086X; 1876-794X
• DOI: 10.1016/j.jiec.2012.08.027

The present research work is intended to synthesize a series of substituted 2,3-dihydro-2-phenylquinazolin-4(1H)-ones using clay-supported heteropolyacid as a novel heterogeneous, reusable and inexpensive catalyst. This catalyst afforded excellent yields in very short reaction times that shows high selectivity without affecting other functional groups, such as carbon–carbon double bond and heterocyclic moieties. The catalyst could be recycled at least six times and reused. The synthesis involves cyclo-condensation of anthranilamide with an aldehyde at room temperature in the presence of small amount of the catalyst. No column purification is required and products can be purified by simple crystallization.