Possible effects of lipoprotein-associated phospholipase A2 single-nucleotide polymorphisms on cardiovascular risk in patients with preeclampsia

• Published in: The journal of maternal-fetal & neonatal medicine Vol. 31; no. 23; pp. 3119 - 3127
• Main Authors: Güngör, Zeynep B., Tüten, Abdullah, Ekmekçi, Hakan, Ekmekçi, Özlem B., Kucur, Mine, Öncül, Mahmut, Donma, Orkide, Madazlı, Rıza, Sönmez, Hüseyin
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02-12-2018
• Subjects: 1-Alkyl-2-acetylglycerophosphocholine Esterase - blood; 1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics; Adult; Biomarkers - blood; C-Reactive Protein - analysis; Cardiovascular Diseases - enzymology; Cardiovascular Diseases - etiology; Cardiovascular Diseases - genetics; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Logistic Models; Lp-PLA2 mass; Lp-PLA2 SNP; Polymorphism, Single Nucleotide; Pre-Eclampsia - enzymology; Pre-Eclampsia - genetics; preeclampsia; Pregnancy; PTX3; Risk Factors; vascular inflammation; vascular inflammation; Lp-PLA2 SNP; PTX3; Lp-PLA2 mass; preeclampsia
• ISSN: 1476-7058; 1476-4954
• DOI: 10.1080/14767058.2017.1365125

Purpose: Lipoprotein lipase-associated phospholipase A2 (Lp-PLA2) is a vascular inflammatory marker associated with cardiovascular diseases (CVD). Women with preeclampsia (PE) have elevated vascular inflammation and at higher CVD risk in the later life. We hypothesize that vascular inflammation related genetic variations increase the risk for developing future cardiovascular disease in women with PE. To test this hypothesis, we studied PLA2G7 gene polymorphisms, Lp-PLA
2
mass, activity, index, and other cardiovascular risk factors in women with preeclampsia.
Methods: A total of 200 pregnant women were included into the study. We stratified the PE group: early (28.7 ± 3.0 weeks) and late onset (36.0 ± 1.4 weeks). Serum Lp-PLA2 mass in the early PE and the late PE group were significantly higher than the control group (p = .000). Lp-PLA2 index, Hs-C-reactive protein (CRP), serum amyloid A (SAA), calprotectin, and PTX3 levels were higher in early and late PE (p = .000). Single-nucleotide mutations of PLA2G7 rs1805017 (r = −0.228, p < .05) and rs9381475 (r = 0.216, p < .05) were correlated with LpPLA2 mass for the early PE group. Logistic regression analysis showed that LP-PA2 mass an independent risk factor for early PE with rs1805017 and rs9381475 carriers.
Conclusions: Lp-PLA2 genetic variability with vascular inflammatory markers might contribute the incidence of future cardiovascular events.