Synthesis, crystal structure and antifungal activity of a Ni(II) complex of a new hydrazone derived from antihypertensive drug hydralazine hydrochloride

• Published in: Polyhedron Vol. 63; pp. 207 - 213
• Main Authors: Nfor, Emmanuel N., Husian, Ahmad, Majoumo-Mbe, Felicite, Njah, Innocent N., Offiong, Offiong E., Bourne, Susan A.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 31-10-2013
• Subjects: Antifungal activity; Crystal structure; Hydralazine hydrochloride; Hydrazone; Ni(II) complex; Square planar; Ni(II) complex; Antifungal activity; Square planar; Hydralazine hydrochloride; Hydrazone; Crystal structure
• ISSN: 0277-5387
• DOI: 10.1016/j.poly.2013.07.028

One mononuclear Ni(II) complex of a bidentate NN donor Schiff base ligand HL (1-(2-[(5-methylfuran-2yl)methylene)] hydrazono) phthalazine) has been synthesized. The structures of the ligand and its complex have been established by single-crystal X-ray diffraction, revealing a square-planar geometric structure for the complex.
The antifungal activity of the ligand and its complex, further investigated against the fungals Aspergillus niger, Aspergillus flavus and Candida albicans showed modest activity.
A new complex of nickel(II) with 1-(2-[(5-methylfuran-2yl)methylene)] hydrazono) phthalazine HL (1) has been synthesized and characterized by elemental analysis, IR, electronic spectra, TGA, 1H and 13C NMR spectroscopy. The crystal structures of the free ligand and its complex have been determined by single crystal X-ray diffraction techniques. In the complex the hydrazone ligand chelates to the nickel(II) through nitrogen atoms in a bidentate manner. The antifungal activity of the ligand and its nickel(II) complex 3 was studied against Aspergillus niger, Aspergillus flavus and Candida albicans. The results revealed modest activity of the complex (3) against the tested organisms with inhibition zones of 14, 14 and 13mm, compared to the free ligand 1 with inhibition zones of 11mm each for A. niger, A. flavus and C. albicans respectively.