Invasive Mechanical Ventilation Is Associated with Worse Right Ventricular Strain in Acute Respiratory Failure Patients

• Published in: Journal of cardiovascular development and disease Vol. 11; no. 8; p. 246
• Main Authors: Wang, Shuyuan, Bashir, Zubair, Chen, Edward W, Kadiyala, Vishnu, Sherrod, Charles F, Has, Phinnara, Song, Christopher, Ventetuolo, Corey E, Simmons, James, Haines, Philip
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09-08-2024; MDPI
• Subjects: acute respiratory failure; Clinical outcomes; Ejection fraction; Hemodynamics; invasive mechanical ventilation; Observational studies; Physiology; Reproducibility; Respiratory failure; right ventricular free wall longitudinal strain; right ventricular global longitudinal strain; TAPSE; Ultrasonic imaging; Ventilators; United States > US; invasive mechanical ventilation; acute respiratory failure; TAPSE; right ventricular free wall longitudinal strain; right ventricular global longitudinal strain
• ISSN: 2308-3425; 2308-3425
• DOI: 10.3390/jcdd11080246

Right ventricular (RV) dysfunction is associated with poor prognosis in acute respiratory failure (ARF). Our study evaluates the efficacy of RV strain in detecting RV dysfunction in ARF patients requiring invasive mechanical ventilation (IMV) compared to tricuspid annular plane systolic excursion (TAPSE). In this retrospective study involving 376 patients diagnosed with ARF and requiring IMV, we extracted clinical and outcome data from patient records. RV global longitudinal strain (RVGLS), free wall longitudinal strain (FWLS), and TAPSE were measured retrospectively using speckle tracking echocardiography (STE) and traditional echocardiography, respectively. We divided the cohort into three groups: TTE during IMV (TTE-IMV, 223 patients), before IMV (TTE-bIMV, 68 patients), and after IMV (TTE-aIMV, 85 patients). Multivariable regression analysis, adjusted for covariates, revealed significantly higher RVGLS and FWLS in the groups not on IMV at the time of TTE compared to the TTE-IMV group. Specifically, the TTE-bIMV group showed higher RVGLS (β = 7.28, 95% CI 5.07, 9.48) and FWLS (β = 5.83, 95% CI 3.36, 8.31), while the TTE-aIMV group exhibited higher RVGLS (β = 9.39, 95% CI 6.10, 12.69) and FWLS (β = 7.54, 95% CI 4.83, 10.24). TAPSE did not reveal any significant differences across the groups. Our study suggests an association between IMV and lower RVGLS and FWLS in ARF patients, indicating that IMV itself may contribute to RV dysfunction. RVGLS and FWLS appear to be more sensitive than TAPSE in detecting changes in RV function that were previously subclinical in patients on IMV. Prospective studies with TTE before, during, and after IMV are necessary to assess the primary driver of RV dysfunction and to prognosticate STE-detected RV dysfunction in this population.