Relevance of circulating MiRNA-21 and MiRNA-181 in prediction of glioblastoma multiforme prognosis

• Published in: Archives of physiology and biochemistry Vol. 128; no. 4; pp. 924 - 929
• Main Authors: Labib, Esraa M., Ezz El Arab, Lobna R., Ghanem, Hala M., Hassan, Rasha E., Swellam, Menha
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04-07-2022
• Subjects: Glioblastoma multiforme; MiRNA; prediction; prognosis; response; prediction; Glioblastoma multiforme; prognosis; response; MiRNA
• ISSN: 1381-3455; 1744-4160
• DOI: 10.1080/13813455.2020.1739716

Authors aimed to investigate the clinical role of miR-21 and miR-181 among glioblastoma multiforme (GBM) patients.
Expression for both miRs were detected in blood samples from newly diagnosed twenty GBM patients before and after treatment along with 20 healthy individuals using QPCR technology.
MiR-21 reported increase expression while miR-181 reported decreased expression in GBM patients. Expression of miR-21 was up-regulated in GBM patients older than 60 years and frontal mass with tumor size > 5 cm while miR-181 expression was down-regulated among them. Worse PFS and OS reported increase in miR-21 expression and decrease in miR-181 expression.
Detection of miR-21 and miR-181 expression levels may be a potential diagnostic and predictors for GBM prognosis.