How to get away with liver innate immunity? A viruses’ tale

How to get away with liver innate immunity? A viruses’ tale

In their never‐ending quest towards persistence within their host, hepatitis viruses have developed numerous ways to counteract the liver innate immunity. This review highlights the different and common mechanisms employed by these viruses to (i) establish in the liver (passive entry or active evasi...

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Bibliographic Details
Published in:Liver international Vol. 41; no. 11; pp. 2547 - 2559
Main Authors: Delphin, Marion, Desmares, Manon, Schuehle, Svenja, Heikenwalder, Mathias, Durantel, David, Faure‐Dupuy, Suzanne
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc 01-11-2021
Wiley-Blackwell
Subjects:
anti‐inflammatory
hepatic viruses
Hepatitis
Immune response
Immune system
Immunity
Immunomodulation
Innate immunity
Interferon
Life Sciences
Liver
MHC
Modulation
NF‐κB
Pattern recognition
Pattern recognition receptors
Phenotypes
pro‐inflammatory
PRR
Signal transduction
Viruses
NF-κB
PRR
innate immunity
liver
hepatic viruses
anti-inflammatory
MHC
interferon
pro-inflammatory
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Description
Summary:In their never‐ending quest towards persistence within their host, hepatitis viruses have developed numerous ways to counteract the liver innate immunity. This review highlights the different and common mechanisms employed by these viruses to (i) establish in the liver (passive entry or active evasion from immune recognition) and (ii) actively inhibit the innate immune response (ie modulation of pattern recognition receptor expression and/or signalling pathways, modulation of interferon response and modulation of immune cells count or phenotype).
Bibliography:Funding information
et les hépatites virales, several grants from this study section 12 [CSS12]).
Agence Nationale de Recherche sur le Sida
Luca Valenti
Marion Delphin, Manon Desmares, and Svenja Schuehle contributed equally.
Handling Editor
SS, MH and SFD were supported by SFBTR179 and German‐Israeli Cooperation in Cancer Research (DKFZ‐MOST). MD, MDS and DD were supported by INSERM (Institut National de la Santé et de la Recherche Médicale; salaries and core‐fundings) and ANRS
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.15054