Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function

• Published in: Gut Vol. 12; no. 10; pp. 773 - 782
• Main Authors: Gleeson, M. H., Bloom, S. R., Polak, J. M., Henry, K., Dowling, R. H.
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01-10-1971
• Subjects: Adult; Biological Assay; Biopsy; Female; Fluorescent Antibody Technique; Gastrointestinal Motility; Glucagon - analysis; Glucagon - blood; Glucagon - metabolism; Histocytochemistry; Hormones, Ectopic - metabolism; Humans; Intestinal Absorption; Intestine, Small - diagnostic imaging; Jejunum - pathology; Kidney Neoplasms - metabolism; Kidney Neoplasms - pathology; Kidney Neoplasms - physiopathology; Kidney Neoplasms - surgery; Microscopy, Electron; Nephrectomy; Radiography; Radioimmunoassay
• ISSN: 0017-5749; 1468-3288
• DOI: 10.1136/gut.12.10.773

A 44-year-old woman is described with an endocrine tumour arising in the kidney. There were associated abnormalities of small intestinal morphology, motility, and absorptive function. These abnormalities reversed on removal of the tumour. Detailed studies showed that the tumour contained, and was secreting, glucagon. It is postulated that the intestinal abnormalities may have resulted from glucagon itself or another, as yet unidentified, hormone.