Toxic effects of subchronic oral acetamiprid exposure in rats

• Published in: Toxicology and industrial health Vol. 35; no. 11-12; pp. 679 - 687
• Main Authors: Karaca, Bahar Ulus, Arican, Yağmur Emre, Boran, Tugce, Binay, Sevgi, Okyar, Alper, Kaptan, Engin, Özhan, Gül
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-11-2019; Sage Publications Ltd
• Subjects: Acetylcholine receptors (nicotinic); Alanine; Alanine transaminase; Alanine Transaminase - blood; Animals; Aspartate aminotransferase; Aspartate Aminotransferases - blood; Biomarkers - metabolism; Chemical and Drug Induced Liver Injury - etiology; Cholesterol; Cholesterol - blood; Creatinine; Creatinine - blood; Damage; Exposure; Glutathione - metabolism; Immune system; Kidney - metabolism; Kidney - pathology; Kidneys; Liver; Liver - metabolism; Liver - pathology; Male; Malondialdehyde - metabolism; Neonicotinoids - toxicity; Oxidative Stress; Rats, Sprague-Dawley; Receptors; Rodents; Toxicity; Urea; Urea - blood; Uric acid; Uric Acid - blood; Acetamiprid; kidney; oxidative damage; nephrotoxicity; liver; hepatotoxicity
• ISSN: 0748-2337; 1477-0393
• DOI: 10.1177/0748233719893203

Acetamiprid, a selective agonist of type-2 nicotinic acetylcholine receptors, is one of the most widely used neonicotinoids. The hepato- and nephrotoxic potential of acetamiprid has not been clarified although it is known to be toxic to other several organ systems, including the nervous, respiratory and immune systems. The present study aimed to investigate acetamiprid liver and kidney toxicity in male rats after a 90-day subchronic exposure to 12.5, 25 and 35 mg/kg. The biochemical and oxidative damage parameters were determined in the plasma and tissue samples as well as histopathological evaluation in the liver and kidney tissues. Acetamiprid caused oxidative damage and affected the liver, denoted by injury markers including the levels of cholesterol, and alanine aminotransferase and aspartate aminotransferase enzymes. There was also a decrease in plasma urea, uric acid and creatinine levels, all of which might result from liver injury. Additionally, acetamiprid was more toxic to the liver than the kidney according to the histopathological examinations. In conclusion, acetamiprid exhibited hepatotoxic potential at all treatment doses on male Sprague Dawley rats.