Management of Hypertrophic Cardiomyopathy in a Newborn with Dextro-Transposition of the Great Arteries

• Published in: Pediatric cardiology Vol. 43; no. 4; pp. 926 - 929
• Main Authors: Bigelow, Amee M., Ball, Molly K., Galantowicz, Mark, Fernandez, Richard P., Gauntt, Jennifer, Texter, Karen M.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-04-2022; Springer
• Subjects: Arteries; Cardiac Surgery; Cardiology; Cardiomyopathy, Hypertrophic; Case Report; Esmolol; Female; Glucose metabolism; Humans; Infant; Infant, Newborn; Medicine; Medicine & Public Health; Neonatology; Physiological aspects; Pregnancy; Retrospective Studies; Transposition of great arteries; Transposition of Great Vessels - diagnosis; Transposition of Great Vessels - surgery; Ultrasonography, Prenatal; Vascular Surgery; Hypertrophic cardiomyopathy; Fetal diagnosis; Transposition of the great arteries; Prenatal multidisciplinary approach; Critical care management
• ISSN: 0172-0643; 1432-1971
• DOI: 10.1007/s00246-022-02874-4

Impaired maternal glucose metabolism during pregnancy can have significant effects on the cardiovascular system of the developing fetus. Early in pregnancy the teratogenic effects may lead to structural heart defects, while later in gestation a form of hypertrophic cardiomyopathy can develop due to overgrowth driven by fetal hyperinsulinism. We describe an infant with the uncommon combination of both dextro-transposition of the great arteries and hypertrophic cardiomyopathy. We emphasize the importance of a longitudinal multi-disciplinary approach, from fetal diagnosis to post-operative management, that allowed for an excellent outcome in this rare combination of severe cardiac malformations.