Required HLB Determination of Some Pharmaceutical Oils in Submicron Emulsions

• Published in: Journal of dispersion science and technology Vol. 33; no. 6; pp. 816 - 820
• Main Authors: Schmidts, T., Schlupp, P., Gross, A., Dobler, D., Runkel, F.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Taylor & Francis Group 01-06-2012; Taylor & Francis; Taylor & Francis Ltd
• Subjects: Chemistry; Colloidal state and disperse state; Emulsions. Microemulsions. Foams; Exact sciences and technology; General and physical chemistry; HLB; Pharmaceuticals; required HLB; Sorbitan oleate; submicron emulsion; Emulsion; Oil; submicron emulsion; Stearate; Fatty ester; Sorbitan oleate; Equation; Calculation; Emulsifier; Fatty acids; required HLB; HLB
• ISSN: 0193-2691; 1532-2351
• DOI: 10.1080/01932691.2011.584800

Different calculations of the hydrophilie-lipophilie balance (HLB) value of Sorbitan fatty acid ester are discussed in literature. Influence on the required HLB value of ethyl oleate was investigated using several emulsifier blends: Span 80/Tween 20, Oleth-3/Steareth-20, Oleth-5/Steareth-20, Oleth-3/PEG-40-Stearate. The calculations of the HLB value of Span 80 have a bearing influence on the determination of the required HLB value. The postulated transferability of the determined required HLB value by the Tween 20/Span 80 system compared to other emulsifier systems is depending on the used equation. Additionally, the required HLB values of the pharmaceutical oils coco-caprate/caprylate and cetearyl isononanoate were determined empirically by preparing submicron emulsions.