Sulfation pathway of thyroid hormone metabolism in selenium-deficient male rats

• Published in: The American journal of physiology Vol. 268; no. 4; pp. E572 - E579
• Main Authors: Wu, S.Y. (Department of Veterans Affairs Medical Center, Long Beach, CA.), Huang, W.S, Chopra, I.J, Jordan, M, Alvarez, D, Santini, F
• Format: Journal Article
• Language: English
• Published: United States 01-04-1995
• Subjects: Animals; Body Weight; CARENCE EN OLIGOELEMENT; DEFICIENCIA DE OLIGOELEMENTOS; Female; Glutathione Peroxidase - metabolism; Iodide Peroxidase - metabolism; Kinetics; Male; METABOLISME; METABOLISMO; Organ Size; RAT; RATA; Rats; Rats, Sprague-Dawley; SELENIO; SELENIUM; Selenium - deficiency; Sex Characteristics; SULFATE; Sulfates - metabolism; SULFATOS; Thyroid Hormones - metabolism; Thyronines - blood; Thyronines - metabolism; THYROXINE; TIROXINA; VIA BIOQUIMICA DEL METABOLISMO; VOIE BIOCHIMIQUE DU METABOLISME
• ISSN: 0002-9513; 2163-5773
• DOI: 10.1152/ajpendo.1995.268.4.e572

Male Sprague-Dawley rats were fed a selenium-deficient yeast-based laboratory diet or a control diet for 6 wk. The tissue type I 5'-monodeiodinase (5'-MDI) activity and the immunoassayable 5'-MDI were significantly (P 0.05) reduced in the liver and the kidney but not in the thyroid of selenium-deficient rats. The mean serum concentrations of thyroxine sulfate (T4S), 3,3',5'-triiodothyronine sulfate (T3S), and reverse T3 sulfate (rT3S) (ng/dl) were significantly increased in selenium-deficient rats (15.7, 59.4, and 22.8, respectively, n 0.05). In conclusion, our data suggest that reduced activity of MDI in tissues of selenium-deficient rats is associated with a significant "shunting" of T3 and T4 into sulfation pathways. These data are also consistent with the hypothesis that there may be a hidden pool for sulfated iodothyronines