Printing medicines as orodispersible dosage forms: Effect of substrate on the printed micro-structure

• Published in: International journal of pharmaceutics Vol. 509; no. 1-2; pp. 518 - 527
• Main Authors: Planchette, C., Pichler, H., Wimmer-Teubenbacher, M., Gruber, M., Gruber-Woelfler, H., Mohr, S., Tetyczka, C., Hsiao, W.-K., Paudel, A., Roblegg, E., Khinast, J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25-07-2016
• Subjects: Administration, Oral; Chemistry, Pharmaceutical - methods; Coating; Dosage Forms; Doses combination; Drug Delivery Systems - methods; Excipients - chemistry; Geriatric; Ink formulation; Inkjet printing; Nanosuspension; Orodispersible dosage form; Patient adherence; Pediatric; Personalized medicine; Pharmaceutical Preparations - chemistry; Pharmaceutical Solutions - chemistry; Precision medicine; Precision Medicine - methods; Printed medicine; Printing - methods; Surface Properties; Technology, Pharmaceutical - methods; Viscosity; Precision medicine; Doses combination; Orodispersible dosage form; Geriatric; Printed medicine; Ink formulation; Inkjet printing; Nanosuspension; Coating; Personalized medicine; Pediatric; Patient adherence
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2015.10.054

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We present our recent advancements in developing a viable manufacturing process for printed medicine. Our approach involves using a non-contact printing system that incorporates both piezoelectric- and solenoid valve-based inkjet printing technologies, to deliver both active and inactive pharmaceutical materials onto medical-graded orodispersible films. By using two complimentary inkjet technologies, we were able to dispense an extensive range of fluids, from aqueous drug solutions to viscous polymer coating materials. Essentially, we demonstrate printing of a wide range of formulations for patient-ready, orodispersible drug dosage forms, without the risk of drug degradation by ink heating and of substrate damages (by contact printing). In addition, our printing process has been optimized to ensure that the drug doses can be loaded onto the orally dissolvable films without introducing defects, such as holes or tears, while retaining a smooth surface texture that promotes patient adherence and allows for uniform post-coatings. Results show that our platform technology can address key issues in manufacturing orodispersible drug dosage forms and bring us closer to delivering personalized and precision medicine to targeted patient populations.