Dendrimers as a promising tool in ocular therapeutics: Latest advances and perspectives

• Published in: International journal of pharmaceutics Vol. 511; no. 1; pp. 359 - 366
• Main Authors: Rodríguez Villanueva, Javier, Navarro, Manuel Guzmán, Rodríguez Villanueva, Laura
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10-09-2016
• Subjects: Administration, Ophthalmic; Animals; Complexation; Dendrimers; Dendrimers - administration & dosage; Dendrimers - metabolism; Drug Carriers - administration & dosage; Drug Carriers - metabolism; Drug Delivery Systems - methods; Encapsulation; Eye Diseases - drug therapy; Eye Diseases - metabolism; Humans; Pharmaceutical Preparations - administration & dosage; Pharmaceutical Preparations - metabolism; Safety; Targeting; Transfectants; Encapsulation; Complexation; Dendrimers; Safety; Targeting; Transfectants
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2016.07.031

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Dendrimers have called the attention of scientists in the area of drug and gene delivery over the last two decades for their versatility, complexity and multibranching properties. Some strategies for optimizing drug pharmacokinetics and site-specific targeting using dendrimers have been proposed. Among them, those related to treating and managing ocular diseases are of special interest. Ocular therapies suffer from significant disadvantages, including frequent administration, poor penetration and/or rapid elimination. This review provides an overview of the recent and promising progress in the dendrimers field, focusing on both the anterior and posterior segments of the eye ocular targets, the use of dendrimers as a strategy for overcoming obstacles to the traditional treatment of ocular diseases and an outlook on future directions. Finally, a first approach to ocular safety with dendrimers is intended that accounts for the state-of-the-art science to date.