Platelet membrane camouflaged nanoparticles: Biomimetic architecture for targeted therapy

• Published in: International journal of pharmaceutics Vol. 598; p. 120395
• Main Authors: Kunde, Shalvi Sinai, Wairkar, Sarika
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-04-2021
• Subjects: Biomimetic nanoparticles; Cancer; Cell membranes; Platelets; Targeted delivery; Cell membranes; Biomimetic nanoparticles; Platelets; Targeted delivery; Cancer
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2021.120395

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Cell membrane coating strategy is one of the promising techniques for biomimetic functionalization of nanoparticle. The biomimetic nanoparticles camouflage themselves utilizing the fundamental properties of native cells. Cell membranes are extracted from various cells to cloak the nanoparticles for targeted drug delivery. Platelet membrane is one such cell membrane proposing itself as a potential camouflager to escape the immune surveillance and aid prolonged blood circulation with minimum systemic cytotoxicity. Platelets play a very important role in the physiological functions of the body and also feature in few pathological disorders like cancer, atherosclerosis and rheumatoid arthritis. This review comprises of preparation and characterization of platelet membrane camouflaged nanoparticles and also focuses on their recent developments towards targeted therapy in cancer, immune diseases, atherosclerosis and phototherapy. Although platelet membrane camouflaged nanoparticles are currently in the preliminary stage of development, there is huge potential to explore this biodegradable and biocompatible delivery system.