Dendritic cell-targeting polymer nanoparticle-based immunotherapy for cancer: A review

Dendritic cell-targeting polymer nanoparticle-based immunotherapy for cancer: A review

Created with BioRender.com [Display omitted] Cancer immunity is dependent on dynamic interactions between T cells and dendritic cells (DCs). Polymer-based nanoparticles target DC receptors to improve anticancer immune responses. In this paper, DC surface receptors and their specific coupling natural...

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Bibliographic Details
Published in:International journal of pharmaceutics Vol. 635; p. 122703
Main Authors: Hu, Yeye, Zhang, Wei, Chu, Xiaozhong, Wang, Aoran, He, Ziliang, Si, Chuan-Ling, Hu, Weicheng
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 25-03-2023
Subjects:
Dendritic cell
Dendritic Cells
Humans
Immunity
Immunotherapy
Nanoparticles
Neoplasms - drug therapy
Polymer
Polymers
Receptor
Target
Dendritic cell
Polymer
Target
Receptor
Immunity
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Summary:Created with BioRender.com [Display omitted] Cancer immunity is dependent on dynamic interactions between T cells and dendritic cells (DCs). Polymer-based nanoparticles target DC receptors to improve anticancer immune responses. In this paper, DC surface receptors and their specific coupling natural ligands and antibodies are reviewed and compared. Moreover, reaction mechanisms are described, and the synergistic effects of immune adjuvants are demonstrated. Also, extracellular-targeting antigen-delivery strategies and intracellular stimulus responses are reviewed to promote the rational design of polymer delivery systems.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2023.122703