Diagnostic Utility of BCOR Antibody in Clear Cell Sarcomas of Kidney

• Published in: International journal of surgical pathology Vol. 28; no. 5; pp. 477 - 481
• Main Authors: Khan, Muhammad Zeeshan, Akhtar, Noreen, Hassan, Usman, Mushtaq, Sajid
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01-08-2020; SAGE PUBLICATIONS, INC
• Subjects: Antibodies; Biomarkers, Tumor - analysis; Child, Preschool; Female; Humans; Immunohistochemistry; Immunohistochemistry - methods; Infant; Kidney cancer; Kidney Neoplasms - diagnosis; Male; Pediatrics; Proto-Oncogene Proteins - analysis; Proto-Oncogene Proteins - biosynthesis; Repressor Proteins - analysis; Repressor Proteins - biosynthesis; Sarcoma; Sarcoma, Clear Cell - diagnosis; Tumors; clear cell sarcoma of kidney; BCL6 corepressor; BCOR; immunohistochemistry; congenital mesoblastic nephroma; Wilms tumor
• ISSN: 1066-8969; 1940-2465
• DOI: 10.1177/1066896919895119

Purpose. Clear cell sarcoma of the kidney (CCSK) is an uncommon malignant renal tumor. It is the second most common renal pediatric renal malignancy after Wilms tumor. It exhibits a heterogeneous morphology, with overlapping features with its close differentials, which results in diagnostic challenges. There was no specific immunohistochemical marker in the past, to help in this regard. BCOR antibody has recently been suggested to be helpful in the differential diagnosis. We aim to study the utility of the BCOR antibody in the diagnosis of CCSK. Methods. We selected a total of 27 cases of CCSK (n = 12), Wilms tumor (n = 12), and congenital mesoblastic nephroma (n = 3). All cases were evaluated for the extent and intensity of nuclear labeling for BCOR antibody by immunohistochemistry (IHC). Results. We found that BCOR IHC was positive in 11 out of 12 cases with diffuse and strong staining in 8 of the cases. None of the cases of Wilms tumor and congenital mesoblastic nephroma were positive. Only 2 cases of Wilms tumor showed minimal and weak staining in <5% of cells. Conclusion. Diffuse and strong nuclear staining for the BCOR antibody is highly specific for CCSK among common pediatric renal malignancies. Our study confirms that BCOR IHC is a good IHC marker for the diagnosis of CCSK.