Application of lanthanum stearate monolayers as a metal-affinity sorbent for the selective sorption of soman adducts to human serum albumin

• Published in: Talanta (Oxford) Vol. 195; pp. 728 - 731
• Main Authors: Babakov, V.N., Shreiner, E.V., Keltsieva, O.A., Dubrovskii, Y.A., Shilovskikh, V.V., Zorin, I.M., Sukhodolov, N.G., Zenkevich, I.G., Podolskaya, E.P., Selyutin, A.A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-04-2019
• Subjects: Adsorption; Adult; Humans; Langmuir-Blodgett films; Lanthanum - chemistry; Lanthanum stearate; Male; Middle Aged; Organophosphorous compounds (OPs); Serum albumin adducts; Serum Albumin, Human - chemistry; Soman - chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stearates - chemistry; Lanthanum stearate; Langmuir-Blodgett films; Serum albumin adducts; Organophosphorous compounds (OPs)
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2018.11.103

A new metal-affinity sorbent based on lanthanum stearate monolayers has been developed and characterized. The prospect of its application to specific extraction of organophosphorous compound (OP) adducts of blood proteins was demonstrated. For this, the patterns of soman adducts of human serum albumin (HSA) were comprehensively characterized by matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS).
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•A new metal-affinity sorbent based on lanthanum stearate monolayers has been developed and characterized.•Specific extraction of organophosphorus compounds adducts with blood proteins has been demonstrated.•Lanthanum(III) stearate films are structures providing a stable framework with La(III) ions incorporated on film surface.•Sorbent does not catalyze hydrolysis of the soman residue bound to tyrosine.