Outcome of T1N0M0 breast cancer in relation to St. Gallen risk assignment criteria for adjuvant therapy

• Published in: Breast (Edinburgh) Vol. 18; no. 4; pp. 263 - 266
• Main Authors: Garassino, I, Gullo, G, Orefice, S, Tondulli, L, Masci, G, Salvini, P, Eboli, M, Di Tommaso, L, Giordano, L, Alloisio, M, Roncalli, M, Santoro, A
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-08-2009
• Subjects: Adjuvant therapy; Adult; Aged; Aged, 80 and over; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Breast Neoplasms - therapy; Combined Modality Therapy; Conservative surgery; Early breast cancer; Female; Hematology, Oncology and Palliative Medicine; Humans; Kaplan-Meier Estimate; Middle Aged; Neoplasm Recurrence, Local - epidemiology; Neoplasm Staging; Prognosis; Prognostic factors; Retrospective Studies; Risk Assessment; St. Gallen consensus meeting; Stage I breast cancer; Survival Analysis; Stage I breast cancer; Conservative surgery; Early breast cancer; St. Gallen consensus meeting; Adjuvant therapy; Prognostic factors
• ISSN: 0960-9776; 1532-3080
• DOI: 10.1016/j.breast.2009.07.003

Abstract T1N0M0 (stage I) breast cancer (BC) has been increasing in recent decades but the optimal adjuvant approach remains controversial. To assess the outcome of BC patients stratified and treated with multimodal therapies according to St. Gallen consensus meeting recommendations, we retrospectively evaluated an unselected cohort of T1N0M0 BC patients, with respect to the St. Gallen criteria. At a median follow-up of 5 years, the recurrence rate, recurrence-free survival and overall survival were 7%, 94% and 96% respectively, and 60% of relapses were locoregional. No statistically significant difference was observed between T1a,b/T1c groups, or among risk categories (high/intermediate/low). The very low rate of distant recurrences even in patients with unfavorable prognostic factors seems to support the use of adjuvant systemic therapies but better prognostic and predictive factors are strongly needed for this subset of patients.