Gastrodia elata extract exerts anti-obesity effects on obese mice caused by a high-starch diet by suppressing SREBP-1 and ChREBP

• Published in: Journal of King Saud University. Science Vol. 35; no. 9; p. 102913
• Main Authors: Lee, Jung-Han, Antonisamy, Paulrayer, Choi, Han-Byeol, Woo, Su-Hyeon, Kim, Chang-Su, Lee, Eun-Suk, Choi, So-Ra, Kwon, Kang-Beom
• Format: Journal Article
• Language: English
• Published: Elsevier 01-12-2023
• Subjects: Anti-obesity; ChREBP; Gastrodia elata; High starch diet; SREBP-1
• ISSN: 1018-3647
• DOI: 10.1016/j.jksus.2023.102913

Objective: Gastrodia elata (GE), a natural treatment, is extensively used in traditional Korean medicine. The study's goal was to look into how GE affected obese mice that had been fed a high-starch diet (HSD). Methods: The C57BL/6 J mice used in this investigation were given HSD to make them obese. Gastrodia elata extract (GEE) was administered orally to the mice throughout the course of the next five weeks in doses of 100, 200, and 500 mg/kg. When the experiment was over, we measured the animals body weight, liver and fat weight, blood biochemical parameters, and gene expression that is related to obesity. Results: The overall body weight of animals was dramatically lowered via GEE oral treatment. In comparison to the HSD group, the serum and liver TG levels were considerably lower in the GEE-treated group. Additionally, regional fatty tissues and liver weight markedly dropped in the GEE-treated batch in comparison to the HSD batch. We observed considerably lower levels of PPAR-γ, C/EBP-α, and ChREBP mRNA expression level in the GEE-treated group in addition to lower levels of SREBP-1, ACC, and FAS protein expression. Conclusion: The studies show that GEE has anti-obesity advantages in the mouse model of obesity caused by HSD. Despite the fact that we utilized mice as a model for the experiment rather than people, who have different biochemical pathways, the finding has significant implications for how GEE generally functions.