Raised serum nitrate and nitrite levels in patients with multiple sclerosis

Nitric oxide and its highly reactive derivative peroxynitrite have been implicated as non-specific inflammatory mediators of neuronal and oligodendrocyte damage and death in multiple sclerosis. In a cross-sectional study we found levels of the nitric oxide metabolites nitrate and nitrite to be raise...

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Bibliographic Details
Published in:	Journal of the neurological sciences Vol. 145; no. 1; pp. 77 - 81
Main Authors:	GIOVANNONI, G, HEALES, S. J. R, SILVER, N. C, O'RIORDAN, J, MILLER, R. F, LAND, J. M, CLARK, J. B, THOMPSON, E. J
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Science 1997
Subjects:	Acquired Immunodeficiency Syndrome - blood Adult AIDS/HIV Biological and medical sciences Female HIV-1 Humans Male Medical sciences Middle Aged Multiple Sclerosis - blood Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nervous System Diseases - blood Neurology Nitrates - blood Nitrites - blood Human Nervous system diseases Multiple sclerosis Pathogenesis Nitric oxide Nitrites Central nervous system disease Exploration Serum Nitrates Inflammatory disease
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Summary:	Nitric oxide and its highly reactive derivative peroxynitrite have been implicated as non-specific inflammatory mediators of neuronal and oligodendrocyte damage and death in multiple sclerosis. In a cross-sectional study we found levels of the nitric oxide metabolites nitrate and nitrite to be raised in the serum of patients with demyelinating disease (65.6 microM (SD 32.9)), acquired immune deficiency syndrome (57.9 microM (SD 34.9)) and inflammatory neurological disease (57.5 microM (SD 31.3)), compared with normal control subjects (32.8 microM (SD 12.2)) and patients with non-inflammatory neurological disease (41.1 microM (SD 12.3), p < 0.001). Nitric oxide metabolites were raised in all clinical subtypes of multiple sclerosis, as well as in clinically isolated syndromes compatible with demyelination, and were not related to progressive disease or disability. This study provides further evidence for a role of nitric oxide in the immunopathogenesis of inflammatory diseases of the central nervous system, including multiple sclerosis.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0022-510X 1878-5883
DOI:	10.1016/S0022-510X(96)00246-8