The spatial-temporal dynamics of pulmonary blood flow are altered in pulmonary arterial hypertension

• Published in: Journal of applied physiology (1985) Vol. 134; no. 4; pp. 969 - 979
• Main Authors: Kizhakke Puliyakote, Abhilash S, Prisk, G Kim, Elliott, Ann R, Kim, Nick H, Pazar, Beni, Sá, Rui Carlos, Asadi, Amran K, Hopkins, Susan R
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01-04-2023
• Subjects: Female; Humans; Innovative Methodology; Lung - physiology; Magnetic Resonance Imaging - methods; Protons; Pulmonary Arterial Hypertension; Pulmonary Circulation - physiology; fluctuation dispersion; functional lung imaging; pulmonary vascular dynamics; arterial spin labeling; perfusion defect
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.00463.2022

Global fluctuation dispersion (FDglobal), a spatial-temporal metric derived from serial images of the pulmonary perfusion obtained with MRI-arterial spin labeling, describes temporal fluctuations in the spatial distribution of perfusion. In healthy subjects, FDglobal is increased by hyperoxia, hypoxia, and inhaled nitric oxide. We evaluated patients with pulmonary arterial hypertension (PAH, 4F, aged 47 ± 15, mean pulmonary artery pressure 48 ± 7 mmHg) and healthy controls (CON, 7F, aged 47 ± 12) to test the hypothesis that FDglobal is increased in PAH. Images were acquired at ∼4-5 s intervals during voluntary respiratory gating, inspected for quality, registered using a deformable registration algorithm, and normalized. Spatial relative dispersion (RD = SD/mean) and the percent of the lung image with no measurable perfusion signal (%NMP) were also assessed. FDglobal was significantly increased in PAH (PAH = 0.40 ± 0.17, CON = 0.17 ± 0.02,
= 0.006, a 135% increase) with no overlap in values between the two groups, consistent with altered vascular regulation. Both spatial RD and %NMP were also markedly greater in PAH vs. CON (PAH RD = 1.46 ± 0.24, CON = 0.90 ± 0.10,
= 0.0004; PAH NMP = 13.4 ± 6.1%; CON = 2.3 ± 1.4%,
= 0.001 respectively) consistent with vascular remodeling resulting in poorly perfused regions of lung and increased spatial heterogeneity. The difference in FDglobal between normal subjects and patients with PAH in this small cohort suggests that spatial-temporal imaging of perfusion may be useful in the evaluation of patients with PAH. Since this MR imaging technique uses no injected contrast agents and has no ionizing radiation it may be suitable for use in diverse patient populations.
Using proton MRI-arterial spin labeling to obtain serial images of pulmonary perfusion, we show that global fluctuation dispersion (FDglobal), a metric of temporal fluctuations in the spatial distribution of perfusion, was significantly increased in female patients with pulmonary arterial hypertension (PAH) compared with healthy controls. This potentially indicates pulmonary vascular dysregulation. Dynamic measures using proton MRI may provide new tools for evaluating individuals at risk of PAH or for monitoring therapy in patients with PAH.