Experimental model of intracranial hypertension with continuous multiparametric monitoring in swine

• Published in: Arquivos de neuro-psiquiatria Vol. 71; no. 10; pp. 802 - 806
• Main Authors: Andrade, Almir Ferreira de, Soares, Matheus Schmidt, Patriota, Gustavo Cartaxo, Belon, Alessandro Rodrigo, Paiva, Wellingson Silva, Bor-Seng-Shu, Edson, Oliveira, Marcelo de Lima, Nascimento, Clarissa Nóbrega, Noleto, Gustavo Sousa, Alves Junior, Aderaldo Costa, Figueiredo, Eberval Gadelha, Otoch, José Pinhata, Teixeira, Manoel Jacobsen
• Format: Journal Article
• Language: English
• Published: Brazil Academia Brasileira de Neurologia - ABNEURO 01-10-2013; Academia Brasileira de Neurologia (ABNEURO)
• Subjects: Acute Disease; Algorithms; Animals; Disease Models, Animal; doppler transcraniana; Intracranial Hypertension - physiopathology; modelos experimentais; Neurophysiological Monitoring - methods; NEUROSCIENCES; Oximetry; Pilot Projects; pressao intracraniana; PSYCHIATRY; Reference Values; Reproducibility of Results; Swine; Time Factors; Ultrasonography, Doppler, Transcranial; ultrassonografia; doppler transcraniana; pressao intracraniana; experimental model; intracranial hypertension; ultrassonografia; transcranial doppler sonography; modelos experimentais
• ISSN: 0004-282X; 1678-4227; 1678-4227; 0004-282X
• DOI: 10.1590/0004-282X20130126

Intracranial hypertension (IH) develops in approximately 50% of all patients with severe traumatic brain injury (TBI). Therefore, it is very important to identify a suitable animal model to study and understand the pathophysiology of refractory IH to develop effective treatments.
We describe a new experimental porcine model designed to simulate expansive brain hematoma causing IH. Under anesthesia, IH was simulated with a balloon insufflation. The IH variables were measured with intracranial pressure (ICP) parenchymal monitoring, epidural, cerebral oximetry, and transcranial Doppler (TCD).
None of the animals died during the experiment. The ICP epidural showed a slower rise compared with parenchymal ICP. We found a correlation between ICP and cerebral oximetry.
The model described here seems useful to understand some of the pathophysiological characteristics of acute IH.