Bioactive polyketides from the fungus Astrocystis sp. BCC 22166

• Published in: Tetrahedron Vol. 70; no. 12; pp. 2129 - 2133
• Main Authors: Kornsakulkarn, Jittra, Saepua, Siriporn, Komwijit, Somjit, Rachtawee, Pranee, Thongpanchang, Chawanee
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 25-03-2014
• Subjects: Antibacterial materials; Astrocystis sp; Bacillus cereus; Bioactive secondary metabolites; Biocompatibility; Body centered cubic lattice; Fungi; Polyketides; Spectroscopic analysis; Spectroscopy; Tetrahedrons; Bioactive secondary metabolites; Polyketides; Astrocystis sp
• ISSN: 0040-4020; 1464-5416
• DOI: 10.1016/j.tet.2014.02.004

Five new compounds, phthalide 1, dihydroisocoumarin 2, and 3, pyrone 4, and benzophenone 5, together with nine known compounds, 3,4-dihydro-4,5,8-trihydroxy-3-methylisocoumarin, sclerotinin A, methyl-8-hydroxy-6-methylxanthone-1-carboxylate, sydowinin A, conioxanthone A, 1,3,8-trihydroxy-6-methylxanthone, 1,8-dihydroxy-3-methoxy-6-methylxanthone, coniochaetone B, and xylaranol B, were isolated from the fungus Astrocystis sp. BCC 22166. Structures of these compounds were elucidated using NMR spectroscopic and MS spectrometric analyses. Compound 1 exhibited antibacterial activity against Bacillus cereus (IC50=12.5 μg/mL) while compound 2 showed cytotoxicity to KB and Vero cells (IC50=22.6 and 48.2 μg/mL).
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