Antihyperglycemic property and insulin secreting activity of hydroalcoholic shoot extract of Thymus caramanicus Jalas: A wild predominant source of food additive in folk medicine

• Published in: Journal of functional foods Vol. 46; pp. 128 - 135
• Main Authors: Honari, Najmeh, Pouraboli, Iran, Gharbi, Sedigheh
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-07-2018; Elsevier
• Subjects: Antioxidant; Diabetes mellitus; Glucose transporters; Thymus caramanicus; α-Amylase inhibitory activity; ppA; QUE; NBT; Thymus caramanicus; AST; GLUT2; Glucose transporters; Diabetes mellitus; DM; ALT; SOD; GAE; MDA; Antioxidant; EDTA; HDL-C; PPs; TCE; CAT; α-Amylase inhibitory activity; STZ; SGLT1,2; T. caramanicus; OGTT
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2018.04.052

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•Antihyperglycemic property of hydroalcoholic shoot extract of Thymus caramanicus (TCE) was assessed.•TCE exerted antihyperglycemic, and improved antioxidant status in diabetics.•TCE showed α-amylase inhibitory activity and improved insulin release.•TCE decreased the renal SGLT2 and GLUT2 mRNA levels in diabetics.•TCE includes rosmarinic acid, caffeic acid, rutin, quercetin and luteolin.
Thymus caramanicus Jalas is a plant that is widely used in the Iranian folk medicine; it serves as spices, tea, and herbal medicine. The present research was carried out to investigate its antidiabetic properties. Oral hydroalcoholic shoot extract of T. caramanicus Jalas (TCE; 300 and 500 mg/kg body weight) 30 min before glucose loading have be observed to improve oral glucose tolerance test in diabetic rats at 240 min. Daily TCE administration for 14 days also showed antihyperglycemic, antilipid peroxidative, antioxidant, and α-amylase inhibitory activities. Also, the TCE improved insulin release, lipid profile, liver and kidney function indices and decreased mRNA levels of sodium-glucose co-transporter 2 (SGLT2) and facilitated glucose transporter 2 (GLUT2) in kidney of diabetic rats. Medicinally, TCE contained important bioactive compounds, such as flavonoids (rutin, quercetin, and luteolin) and phenolic acids (rosmarinic and caffeic acids) leading to its adjusted use as a natural remedy in diabetes mellitus.