Three-component indole synthesis using ortho-dihaloarenes

A three-component synthesis of substituted indoles is accomplished starting from ortho-dihaloarenes through the use of a multicatalytic system consisting of an N-heterocyclic carbene palladium complex and CuI. The corresponding indole derivatives are obtained as single regioisomers in high yields of...

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Bibliographic Details
Published in:	Tetrahedron Vol. 61; no. 48; pp. 11311 - 11316
Main Authors:	Kaspar, Ludwig T., Ackermann, Lutz
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 28-11-2005
Subjects:	Indoles Multi-catalytic reaction Multi-component reaction Multi-catalytic reaction Indoles Multi-component reaction
Online Access:	Get full text
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Summary:	A three-component synthesis of substituted indoles is accomplished starting from ortho-dihaloarenes through the use of a multicatalytic system consisting of an N-heterocyclic carbene palladium complex and CuI. The corresponding indole derivatives are obtained as single regioisomers in high yields of isolated product. Graphical Abstract
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2005.09.095