Bariatric surgery in a patient with cystic fibrosis and diabetes: A case report

• Published in: Journal of cystic fibrosis Vol. 22; no. 3; pp. 577 - 579
• Main Authors: Bruijn, N.R.A., Wagenmakers, M.A.E.M., van Hoek, M., Apers, J.A., van der Eerden, M.M., Özcan, B.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-05-2023
• Subjects: Bariatric surgery; Bariatric Surgery - adverse effects; Cystic fibrosis; Cystic Fibrosis - complications; Cystic Fibrosis - diagnosis; Cystic Fibrosis - surgery; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnosis; Humans; Obesity; Obesity - complications; Quality of Life; Obesity; Cystic fibrosis; Diabetes; Bariatric surgery
• ISSN: 1569-1993; 1873-5010
• DOI: 10.1016/j.jcf.2023.01.008

•First case report describing the effect of bariatric surgery in a CF patient with type 2 diabetes.•CF patients with a mild phenotype and overweight/obesity can develop type 2 diabetes.•Bariatric surgery may be considered as a treatment option in obese pancreatic sufficient CF patients.•C-peptide and fasting plasma insulin can be used for differential diagnosis of type 2 diabetes and CF-related diabetes in pancreatic sufficient CF patients.
Cystic fibrosis (CF) is incurable and chronic, causing severe multisystemic damage and long-term complications. The most prominent extrapulmonary long-term complication is CF-related diabetes, which is the most reported form of diabetes in individuals with cystic fibrosis. Here we present the first case of an individual with cystic fibrosis who developed type 2 diabetes due to obesity rather than CF-related diabetes. The type 2 diabetes went into remission due to extreme weight loss after gastric bypass surgery. To our knowledge, this case is also the first report describing the effect of bariatric surgery in a patient with CF. This case demonstrates that patients with CF may present with type 2 diabetes instead of CF-related diabetes. Differential diagnosis of these two types of diabetes is essential for optimal treatment and quality of life.