Resolution of left ventricular thrombus with apixaban in a patient with hypertrophic cardiomyopathy

• Published in: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir Vol. 44; no. 4; pp. 335 - 337
• Main Authors: Kaya, Adnan, Hayıroğlu, Mert İlker, Keskin, Muhammed, Tekkeşin, Ahmet İlker, Alper, Ahmet Taha
• Format: Journal Article
• Language: English
• Published: Turkey KARE Publishing 01-06-2016
• Subjects: Anticoagulants - therapeutic use; apixaban; atrial fibrillation; Cardiomyopathy, Hypertrophic - complications; Cardiomyopathy, Hypertrophic - diagnostic imaging; Female; Heart Diseases - complications; Heart Diseases - diagnostic imaging; Heart Diseases - drug therapy; Heart Diseases - physiopathology; Heart Ventricles - diagnostic imaging; Heart Ventricles - physiopathology; Humans; hypertrophic cardiomyopathy; Middle Aged; Pyrazoles - therapeutic use; Pyridones - therapeutic use; Thrombosis - complications; Thrombosis - diagnostic imaging; Thrombosis - drug therapy; Thrombosis - physiopathology; thrombus
• ISSN: 1016-5169; 1308-4488; 1016-5169
• DOI: 10.5543/tkda.2015.68054

Anticoagulation with warfarin is the main treatment of intracardiac thrombus. While novel oral anticoagulants (NOACs) have been approved by the US Food and Drug Administration (FDA) for stroke prevention in patients with nonvalvular atrial fibrillation (AF), they are not indicated for resolution of intracardiac thrombus. The case of a 60-year-old woman with left ventricular (LV) thrombus secondary to hypertrophic cardiomyopathy and AF is described in the present report. Indications for oral anticoagulation were AF and LV thrombus. Thrombus was dissolved after 1 month of apixaban treatment. To the best of our knowledge, this is the first report that describes the resolution of LV thrombus with apixaban treatment in a patient with hypertrophic cardiomyopathy.