Dietary flavanones and citrus fruits influence cytokines and thyroid transcription factor-1 in an HDM-induced chronic asthma murine model

• Published in: Journal of functional foods Vol. 26; pp. 709 - 718
• Main Authors: Seyedrezazadeh, Ensiyeh, Sabri, Amin, Barzegari, Abolfazl, Kolahian, Saeed, Shahbazfar, Amir-Ali, Ansarin, Khalil, Vafa, Mohammadreza, Sakhinia, Ebrahim
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-10-2016; Elsevier
• Subjects: Asthma; Citrus fruit; Cytokines; Flavanones; Thyroid transcription factor-1; Thyroid transcription factor-1; Flavanones; Cytokines; Citrus fruit; Asthma
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2016.08.033

•Citrus fruit or flavanone effects on airway remodelling features are little known.•Their effects on asthma pro-inflammatory and transcription factors are evaluated.•Grapefruit-orange or hesperetin–naringenin reduced TNF-α and TGF-β expression.•Mixed intake of them may have synergic activities and may ameliorate airway remodelling.
The effects of hesperetin plus naringenin, orange juice and grapefruit juice on mRNA expression of TNF-α, TGF-β1 and TTF-1 in a house dust mite (HDM)-induced asthma animal model were investigated. Interventional mice exposed to HDM for 6 weeks received hesperetin plus naringenin, orange plus grapefruit juice, orange juice, grapefruit juice or water during the last 4 weeks, whereas non-asthmatic control mice consumed water. Lung tissue TNF-α and TGF-β1 expressions in supplemented groups were significantly reduced (p < 0.0001 and p < 0.001, respectively) compared with asthmatic controls. Hesperetin plus naringenin and orange plus grapefruit juice intake reduced expression of TGF-β1 more than grapefruit juice (p ≤ 0.02) or orange juice compared with the asthmatic control group. All supplemented groups had non-significantly higher TTF-1 expression compared with water intake groups. Orange plus grapefruit juice or hesperetin plus naringenin with down-regulation of TNF-α and TGF-β1 may ameliorate lung damage in the lung tissue of asthmatic subjects.