Lactobacillus fermentum and its potential immunomodulatory properties

• Published in: Journal of functional foods Vol. 56; pp. 21 - 32
• Main Authors: Zhao, Yan, Hong, Kan, Zhao, Jianxin, Zhang, Hao, Zhai, Qixiao, Chen, Wei
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-05-2019; Elsevier
• Subjects: Immunomodulatory properties; Inflammatory diseases; Lactobacillus fermentum; Immunomodulatory properties; Inflammatory diseases; Lactobacillus fermentum
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2019.02.044

L. fermentum participates in immune regulation.
Many L. fermentum have demonstrated capacity to promote a Th1 response and participated in the regulation of a series of inflammatory cytokines in inflammatory diseases. Immunomodulatory properties are strain-dependent, and further evidence is needed in order to give to each L. fermentum a specific immune response in the intestinal mucosa.
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•L. fermentum has an anti-inflammatory effect in diverse inflammatory diseases.•L. fermentum can modulate both innate and adaptive immune processes.•L. fermentum commonly lessened TNF-α and increased IL-10 in inflammatory tissues.•Immunomodulatory properties of L. fermentum are strain-dependent.
Lactobacillus fermentum has been used in industrial processes and food fermentation for a long time. Because it is of human origin, non-pathogenic, has high resistance to passing through the intestine, prevents pathogenic insults and promotes the maturation of the immune system, it has been identified as a potential probiotic. L. fermentum has been shown to interact with human immune cells and to modulate specific pathways involved in innate and adaptive immune processes in diverse inflammatory diseases. This review summarizes the immunomodulatory properties and regulatory mechanisms of L. fermentum identified in isolated immune cells, animal models and the human body in recent studies.