Sleep quality in glaucoma patients

• Published in: Scientific reports Vol. 14; no. 1; pp. 25593 - 8
• Main Authors: Bec, Louise, Herber, Romain, Bailly, Sébastien, Van Ngo, Thi Hong, Tamisier, Renaud, Pépin, Jean-Louis, Aptel, Florent, Chiquet, Christophe
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26-10-2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/699/1785; 692/699/3161; 692/699/3161/3172; 692/699/375/1816; Aged; Apnea; Case-Control Studies; Comorbidity; Confounding (Statistics); Female; Glaucoma; Glaucoma - physiopathology; Humanities and Social Sciences; Humans; Hypoxia; Life Sciences; Male; Middle Aged; multidisciplinary; Polysomnography; Prospective Studies; Science; Science (multidisciplinary); Sleep; Sleep - physiology; Sleep disorders; Sleep Quality; Visual field; Glaucoma; Sleep quality; Sleep; Polysomnography
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-76368-z

The purpose of this study is to objectively assess by polysomnography total sleep time and sleep macrostructure in glaucomatous versus non-glaucomatous individuals after adjusting for possible confounding factors affecting the quality of sleep. This is an observational, prospective, single-center, case-controlled study using a sleep research database (MARS e-Cohort) collecting clinical data, comorbidities, medications, and sleep studies of glaucomatous and non-glaucomatous individuals. The diagnosis of glaucoma was confirmed with a full comprehensive ophthalmological examination including a visual field test. Total sleep time and the main sleep parameters (time spent in stages 1, 2, 3 and 4, microarousals, apnea–hypopnea index, and indices of hypoxic burden) were compared in glaucomatous and non-glaucomatous individuals after adjusting for age, anthropometric data, and comorbidities. The study included 33 glaucomatous and 66 non-glaucomatous individuals. The median total sleep time was 325 min [273; 398] for the control group and 311 min [244; 349] for the glaucoma group. After adjusting for the potential confounding factors, there was no significant difference in total sleep time (
p
 = 0.3) and other sleep parameters between the control group and the glaucoma group. The sleep macrostructure was comparable in the glaucomatous and non-glaucomatous individuals after careful adjustment for confounders.