Editorial: Molecular underpinnings of relapse-like behavior: drug context and development

• Published in: Frontiers in behavioral neuroscience Vol. 17; p. 1347621
• Main Authors: Orsini, Caitlin A, Kim, Jee Hyun, Arguello, Amy A
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 04-01-2024; Frontiers Media S.A
• Subjects: Abstinence; Behavioral Neuroscience; Cocaine; cocaine conditioned place preference; cocaine self-administration; Cognition & reasoning; Cognitive ability; Decision making; Drug self-administration; estrous cycle; extinction; Females; relapse; risk-taking behavior; Teenagers; cocaine self-administration; extinction; risk-taking behavior; cocaine conditioned place preference; relapse; adolescent; estrous cycle; ethanol
• ISSN: 1662-5153; 1662-5153
• DOI: 10.3389/fnbeh.2023.1347621

Importantly, relapse behaviors are also observed in animals that receive or self-administer a drug, providing biological tools to understand the human condition (Perry et al., 2014). [...]the current Research Topic aims to gather insight from preclinical studies relevant to drug-taking and seeking to understand the factors underlying SUDs. [...]when the relationship between the magnitude of cocaine intake and subsequent risk-taking behavior was examined, greater cocaine intake predicted greater preference for the risky option in females but not in males. [...]hormonal cyclicity was significantly disrupted in females that self-administered cocaine, and this effect persisted well into abstinence. [...]Arguello et al. provide a review of rodent studies that utilize cocaine CPP and cocaine self-administration to understand the impact of adolescent cocaine use on subsequent reward, craving and relapse-like behavior. [...]the present Research Topic highlights sex- and/or age-specific novel neurochemical and cognitive factors that may affect susceptibility to SUDs.