Systemic corticosteroids for orbital complications of pediatric rhinosinusitis: A systematic review

• Published in: International journal of pediatric otorhinolaryngology Vol. 167; p. 111336
• Main Authors: Schwartz, Tyler R., Adams, Matthew D., Wertz, Aileen
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01-04-2023
• Subjects: Abscess - drug therapy; Abscess - etiology; Adrenal Cortex Hormones - therapeutic use; Child; Corticosteroids; Humans; Level of evidence: NA; Pediatric; Retrospective Studies; Sinusitis; Sinusitis - complications; Sinusitis - drug therapy; Steroids; Corticosteroids; Pediatric; Sinusitis; Level of evidence: NA
• ISSN: 0165-5876; 1872-8464
• DOI: 10.1016/j.ijporl.2022.111336

Determine if systemic corticosteroids administration is associated with reduced length of stay, surgical intervention, and abscess formation in pediatric patients with orbital complications of rhinosinusitis.
Systematic review and meta-analysis were performed utilizing the PubMed and MEDLINE databases to identify articles published between January 1990 and April 2020. Retrospective cohort study of the same patient population over the same time period at our institution.
Eight studies, 477 individuals, met criteria for inclusion in the systematic review. 144 patients (30.2%) received systemic corticosteroids, while 333 patients (69.8%) did not. Meta-analyses of frequency of surgical intervention and subperiosteal abscess showed no difference between those who did and did not receive systemic steroids ([OR = 1.06; 95% CI: 0.46 to 2.48] and [OR = 1.08; 95% CI: 0.43 to 2.76], respectively). 6 articles evaluated hospital length of stay (LOS). 3 of these reported enough data to perform meta-analysis, which showed patients with orbital complications who received systemic corticosteroids had shorter mean hospital LOS when compared with those who did not receive systemic steroids (SMD = −2.92, 95% CI: 5.65 to −0.19).
While available literature was limited, systematic review and meta-analysis suggests systemic corticosteroids decrease length of stay for hospitalized pediatric patients with orbital complications of sinusitis. Further research is needed to more clearly define the role of systemic corticosteroids as an adjunctive treatment.