Predictive value of procalcitonin level for pharyngocutaneous fistula after laryngectomy

• Published in: American journal of otolaryngology Vol. 44; no. 4; p. 103846
• Main Authors: Jichao, Sha, Cuida, Meng, Liwei, Sun, Jiani, Li, Dongdong, Zhu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-07-2023
• Subjects: Biomarkers; C-reactive protein; C-Reactive Protein - metabolism; Cutaneous Fistula - diagnosis; Cutaneous Fistula - etiology; Humans; Laryngectomy; Laryngectomy - adverse effects; Middle Aged; Neutrophil percentage; Pharyngocutaneous fistula; Postoperative Complications - diagnosis; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Procalcitonin; Retrospective Studies; White blood cell count; Neutrophil percentage; C-reactive protein; Pharyngocutaneous fistula; White blood cell count; Laryngectomy; Procalcitonin
• ISSN: 0196-0709; 1532-818X
• DOI: 10.1016/j.amjoto.2023.103846

Pharyngocutaneous fistula (PCF) is among the most common postoperative infective complications following laryngectomy. Its diagnosis is often late and identified only after the formation of an abnormal, bacterial infection-harboring fistula track between the pharynx and the skin. This study was aimed at determining whether procalcitonin (PCT), white blood cell count (WBC), C-reactive protein (CRP), and neutrophil percentage are good predictors of PCF.
We prospectively analysed 65 consecutive patients undergoing total laryngectomy. Clinicodemographic, surgical, and body mass index data were collected. Data on serum levels of PCT, WBC, CRP, and neutrophils were obtained before surgery and on postoperative days 2, 4, 6, 8, and 10 by immunofluorescence, immune turbidimetry, and automatic blood analyzer. The area under the receiving operating characteristic (ROC) curve was calculated for each marker.
There were 65 patients with a mean age of 60.34 years. The PCF occurrence rate was 18.46 % (12/65). Serum levels of PCT and CRP determined on postoperative day 2, 4, 6, 8, and 10 after surgery were higher in patients with PCF (P < 0.01). PCT level was identified as a good predictor area under the curve (AUC) > 0.800 on postoperative days 2, 4, and 6. Considering the sensitivity and specificity, the best combination was PCT on postoperative days 4, which with a cutoff level of 0.12 μg/L showed 91.67 % sensitivity and 100 % specificity.
Procalcitonin can predict PCF following laryngectomy. PCT > 0.12 μg/L on postoperative day 4 was a reliable predictor of PCF. This may help guide postoperative antibiotic management.