Roles of circRNAs in prostate cancer: Expression, mechanism, application and potential

• Published in: The international journal of biochemistry & cell biology Vol. 134; p. 105968
• Main Authors: Zhang, Chunlei, Yang, Qi, Li, Weiping, Kang, Yindong, Zhou, Fenghai, Chang, Dehui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-05-2021
• Subjects: circRNAs; Diagnosis; Prognosis; Prostate cancer; Therapy resistance; RBP; circRNAs; lncRNA; Prognosis; OS; PDX; GS; EMT; NEPC; PCa; AUC; Enz; BCR; DFS; DHT; AR; Therapy resistance; RT-PCR; RIN; BPH; CRI; Diagnosis; CRPC; Prostate cancer
• ISSN: 1357-2725; 1878-5875
• DOI: 10.1016/j.biocel.2021.105968

Circular RNA (circRNA) is a member of the non-coding RNA family that is formed by trans-splicing. Because of its unique structure and characteristics, it has extraordinary value for the diagnosis, treatment, and prognosis of diseases, particularly for tumors. Study of the role of circRNAs in the occurrence and development of prostate cancer has made considerable progress, but many areas remain that require further exploration and improvement. This article describes research into sequencing expression profiles, expression regulation, potential value as biomarkers, mechanism in the occurrence and development, therapy resistance, relationship with clinicopathological features, and prognostic value of circRNAs in prostate cancer from the past few years.