Genetic diversity of HLA system in two populations from Sinaloa, Mexico: Culiacán and rural Sinaloa

• Published in: Human immunology Vol. 81; no. 9; pp. 482 - 484
• Main Authors: Clayton, Stephen, Barquera, Rodrigo, Uribe-Duarte, María Guadalupe, Goné Vázquez, Isis, Zúñiga, Joaquín, Arrieta-Bolaños, Esteban, Hernández-Zaragoza, Diana Iraíz, Ruíz-Corral, María de Jesús, Escobedo-Ruíz, Araceli, Arellano-Prado, Francia Paulina, García-Arias, Víctor Eduardo, Rodríguez-López, Marla Estefanía, Bravo-Acevedo, Alicia, Sánchez-Fernández, María Guadalupe de Jesús, Aguilar-Campos, Jesús Abraham, Serrano-Osuna, Ricardo, Gómez-Navarro, Benjamín, Sandoval-Sandoval, Mario J., Yunis, Edmond J., Bekker-Méndez, Carolina, Granados, Julio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-09-2020
• Subjects: Admixture; HLA; Immunogenetics; Population genetics; Sinaloa; Immunogenetics; Admixture; Sinaloa; LD; HLA; Population genetics; MPA
• ISSN: 0198-8859; 1879-1166
• DOI: 10.1016/j.humimm.2019.06.006

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 286 Mexicans from the state of Sinaloa living in Culiacán (N = 103) and rural communities (N = 183) to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes for the state of Sinaloa include ten Native American most probable ancestry and five European most probable ancestry haplotypes. The admixture estimates revealed that the main genetic components in the state of Sinaloa are European (62.39 ± 3.47%) and Native American (37.61 ± 2.85%), while the African genetic component was estimated as virtually absent (0.00 ± 1.86%).