Persisting hepatitis E virus infection leading to liver cirrhosis despite recovery of the immune system in an HIV-infected patient

Summary Chronic hepatitis E has been described several times in strongly immunosuppressed HIV-patients. We describe the persistence of HEV-infection in an HIV-patient despite a restored immune response. This case demonstrates that HEV-infection can persist in formerly immunosuppressed individuals ir...

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Bibliographic Details
Published in:	Clinics and research in hepatology and gastroenterology Vol. 40; no. 3; pp. e23 - e25
Main Authors:	Ingiliz, P, Mayr, C, Obermeier, M, Herbst, H, Polywka, S, Pischke, S
Format:	Journal Article
Language:	English
Published:	France 01-06-2016
Subjects:	Antiviral Agents - therapeutic use DNA, Viral - blood Gastroenterology and Hepatology Hepatitis E - drug therapy Hepatitis E virus - genetics HIV Infections - complications Humans Internal Medicine Liver Cirrhosis - virology Male Middle Aged Ribavirin - therapeutic use
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Summary:	Summary Chronic hepatitis E has been described several times in strongly immunosuppressed HIV-patients. We describe the persistence of HEV-infection in an HIV-patient despite a restored immune response. This case demonstrates that HEV-infection can persist in formerly immunosuppressed individuals irrespective of the current immune status. Persisting HEV-infection can lead to chronic inflammation and liver cirrhosis. Physicians should be aware of the possibility of chronic hepatitis E even in patients that are not any longer immunocompromised. However, ribavirin is an efficient treatment option.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	2210-7401 2210-741X
DOI:	10.1016/j.clinre.2016.01.005