Soluble endoglin versus sFlt-1/PlGF ratio: detection of preeclampsia, HELLP syndrome, and FGR in a high-risk cohort

• Published in: Hypertension in pregnancy Vol. 41; no. 3-4; pp. 159 - 172
• Main Authors: Iannaccone, A., Reisch, B., Mavarani, L., Darkwah Oppong, M., Kimmig, R., Mach, P., Schmidt, B., Köninger, A., Gellhaus, A.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02-10-2022; Taylor & Francis Group
• Subjects: Angiogenic Factors; Biomarkers; Cross-Sectional Studies; Endoglin; Female; Fetal Growth Restriction; Fetal Growth Retardation; HELLP Syndrom; HELLP syndrome; HELLP Syndrome - diagnosis; Humans; IUGR; Placenta; Placenta Growth Factor; Pre-Eclampsia - diagnosis; Preeclampsia; Pregnancy; Vascular Endothelial Growth Factor Receptor-1; Fetal Growth Restriction; HELLP Syndrom; IUGR; Angiogenic Factors; Preeclampsia; HELLP syndrome
• ISSN: 1064-1955; 1525-6065
• DOI: 10.1080/10641955.2022.2066119

The angiogenic factors sFlt-1 and PlGF play an established role in the detection of preeclampsia (PE). Recent data suggest that sEng might contribute to the pathogenesis of PE. However, only a few studies so far have addressed its role.
This monocentric cross-sectional study of high-risk pregnancies aims to compare the levels of sFlt-1/PlGF ratio and sEng depending on different placental-related adverse pregnancy outcomes. The statistical analysis takes into account Pearson's correlation coefficient between angiogenic factors, the area under the curve estimates (AUCs) for detection, and adjusted odds ratios (aOR) with 95% confidence intervals (95%-CIs). The analysis included 206 patients: 60 controls, 90 PE (59 EOPE, 35 LOPE), 94 FGR, and 35 HELLP cases. Some outcomes overlapped because FGR commonly complicated PE and HELLP syndrome. Serum levels of sFlt-1/PlGF and sEng correlated with each other. Higher levels were observed in HELLP syndrome and EOPE cases. AUCs for sFlt-1/PlGF ratio and sEng were, respectively, 0.915 (95%-Cl 0.87-0.96) and 0.872 (95%-Cl 0.81-0.93) in PE, 0.895 (95%-Cl 0.83-0.96) and 0.878 (95%-Cl 0.81-0.95) in HELLP syndrome, 0.891 (95%-Cl 0.84-0.94), and 0.856 (95%-Cl 0.79-0.92) in FGR.aORsfor sFlt-1/PlGF ratio and sEng were, respectively: 2.69 (95%-Cl 1.86-3.9) and 2.33 (95%-Cl 1.59-3.48) in PE, 2.38 (95%-Cl 1.64-3.44) and 2.28 (95%-Cl 1.55-3.4) in FGR, and 2.10 (95%-Cl 1.45-3.05) and 1.88 (95%-Cl 1.31-2.69) in HELLP syndrome. In addition, the aORs between sFlt-1/PlGF and sEng were very similar but higher for PE and FGR than HELLP syndrome.In conclusion,sEng performed similarly to sFlt-1/PlGF to detect placental dysfunctions.