The role of Mrgprs in pain

•Mrgprs are receptors expressed on sensory neurons involved in transmitting itch and pain.•MrgprX1 activation reduces mechanical hypersensitivity in neuropathic pain models.•MrgprB2 and its human homologue MrgprX2 are non-neuronal Mrgprs that modulate neurogenic inflammation after injury. Owing to t...

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Bibliographic Details
Published in:	Neuroscience letters Vol. 744; p. 135544
Main Author:	Green, Dustin P.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 23-01-2021
Subjects:	Animals Ganglia, Spinal - metabolism Ganglia, Spinal - pathology Humans Mast Cells - metabolism Mrgpr Neuroimmune Nociceptors - metabolism Nociceptors - pathology Pain Pain - diagnosis Pain - metabolism Pain Management - methods Receptors, G-Protein-Coupled - metabolism Sensory Receptor Cells - metabolism Sensory Receptor Cells - pathology Mrgpr Neuroimmune Pain
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Summary:	•Mrgprs are receptors expressed on sensory neurons involved in transmitting itch and pain.•MrgprX1 activation reduces mechanical hypersensitivity in neuropathic pain models.•MrgprB2 and its human homologue MrgprX2 are non-neuronal Mrgprs that modulate neurogenic inflammation after injury. Owing to their functional diversity, the Mas-related G-protein-coupled receptor (Mrgpr) family has a role in both itch and pain modulation. While primarily linked to pruritis, Mrgprs were originally characterized in small-diameter nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia. This review will focus on the role Mrgpr’s have in pain physiology, discussing recent discoveries as well as how Mrgpr’s may provide a new target for the treatment of pathological pain.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2020.135544