Genetic diversity of HLA system in two populations from Colima, Mexico: Colima city and rural Colima

• Published in: Human immunology Vol. 81; no. 9; pp. 513 - 515
• Main Authors: Barquera, Rodrigo, Hernández-Zaragoza, Diana Iraíz, Arellano-Prado, Francia Paulina, Goné-Vázquez, Isis, Clayton, Stephen, Arrieta-Bolaños, Esteban, Escobedo-Ruíz, Araceli, García-Arias, Víctor Eduardo, Bravo-Acevedo, Alicia, Rodríguez-López, Marla Estefanía, Sánchez-Fernández, María Guadalupe de Jesús, Sandoval-Sandoval, Mario J., Gómez-Navarro, Benjamín, Zúñiga, Joaquín, Yunis, Edmond J., Bekker-Méndez, Carolina, Granados, Julio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-09-2020
• Subjects: Admixture; Colima; HLA; Immunogenetics; Population genetics; Immunogenetics; Admixture; LD; HLA; Population genetics; Colima; MPA
• ISSN: 0198-8859; 1879-1166
• DOI: 10.1016/j.humimm.2019.06.004

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 104 Mexicans from the state of Colima living in the city of Colima (N = 61) and rural communities (N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Colima include eight Native American, two European and one African haplotype. Admixture estimates revealed that the main genetic components in the state are Native American (52.74 ± 3.88% by ML; 48.10% of Native American haplotypes) and European (37.52 ± 8.94% by ML; 26.66% of European haplotypes), and a relatively high African genetic component (9.74 ± 8.40% by ML; 11.91% of African haplotypes).