Genetics of primary generalized osteoarthritis

Genetics of primary generalized osteoarthritis

Osteoarthritis (OA) is a common joint disease with complex etiology, including biomechanical, biochemical, and genetic components. The genetics of primary idiopathic OA is likely complex as multiple susceptibility loci have been identified from genome-wide scans. The future lies in finer mapping of...

Full description

Saved in:
Bibliographic Details
Published in:Molecular Genetics and Metabolism Vol. 77; no. 1; pp. 31 - 34
Main Author: Scott Simonet, W
Format: Book Review Journal Article
Language:English
Published: United States Elsevier Inc 01-09-2002
Subjects:
Chromosome Mapping
Chromosomes, Human - genetics
Female
Genetic Linkage
Genome, Human
Humans
Male
Osteoarthritis - genetics
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Osteoarthritis (OA) is a common joint disease with complex etiology, including biomechanical, biochemical, and genetic components. The genetics of primary idiopathic OA is likely complex as multiple susceptibility loci have been identified from genome-wide scans. The future lies in finer mapping of these chromosomal regions, association studies, and candidate gene analysis and identification, which should collectively give rise to an improved understanding of the genetic mutations and biological pathways which increase the risk of developing this common joint disorder.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1096-7192
1096-7206
DOI:10.1016/S1096-7192(02)00154-3