Co-occurring psychiatric disorders in young people with eating disorders: An multi-state and real-time analysis of real-world administrative data
We aimed to use real-world data to characterize the burden of psychiatric comorbidities in young people with eating disorders (EDs) relative to peers without EDs. This retrospective cohort study used a large federated multi-national network of real-time electronic health records. Our cohort consiste...
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| Published in: | General hospital psychiatry Vol. 90; pp. 30 - 34 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Elsevier Inc
01-09-2024
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | We aimed to use real-world data to characterize the burden of psychiatric comorbidities in young people with eating disorders (EDs) relative to peers without EDs.
This retrospective cohort study used a large federated multi-national network of real-time electronic health records. Our cohort consisted of 124,575 people (14,524 people receiving their index, first-ever, ED diagnosis, compared to 110,051 peers without EDs initiating antidepressants). After 1:1 propensity score matching of the two cohorts by pre-existing demographic and clinical characteristics, we used multivariable logistic regression to compute the adjusted odds ratio (aOR) of psychiatric diagnoses arising in the year following the index event (either first ED diagnosis or first antidepressant script).
Over 50% of people with EDs had prior psychiatric diagnoses in the year preceding the index EDs diagnosis, with mood disorders, generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), specific phobia (SP), attention-deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD) being the most common. Adjusted analyses showed higher odds for mood disorders (aOR = 1.20 [95% CI = 1.14–1.26]), GAD (aOR = 1.28 [1.21–1.35]), PTSD (aOR = 1.29 [1.18–1.40]), and SP (aOR = 1.45 [1.31–1.60]) in the EDs cohort compared to antidepressant-initiating peers without EDs, although rates of ADHD and ASD were similar in both cohorts.
This large-scale real-time analysis of administrative data illustrates a high burden of co-occurring psychiatric disorders in people with EDs. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Dominic Moog BA - Interpreted the data, drafted the initial version of the paper, reviewed and edited all drafts, and approved the final manuscript. Binx Y. Lin MD MSc – Conceptualized the study, conducted data analyses, conducted data validation, interpreted the data, drafted the initial version of the paper, reviewed and edited all drafts, and approved the final manuscript. Angela Liu MD - Conceptualized the study, interpreted the data, reviewed and edited all drafts, and approved the final manuscript. Hui Xie MPH - Interpreted the data, conducted data analyses, conducted data validation, reviewed and edited all drafts, and approved the final manuscript. Sarah Eddington MD - Interpreted the data, reviewed and edited all drafts, and approved the final manuscript. The corresponding author (Dr. Xu) declares that all co-authors made substantial contributions as outlined below. All co-authors approve the version being submitted to General Hospital Psychiatry. Kevin Y Xu MD MPH - Conceptualized the study, provided supervision, interpreted the data, drafted the initial version of the paper, reviewed and edited all drafts, and approved the final manuscript. |
| ISSN: | 0163-8343 1873-7714 1873-7714 |
| DOI: | 10.1016/j.genhosppsych.2024.06.009 |